micropython/ports/esp32/boards/deploy_s3.md

Program your board using the esptool.py program, found here.

If you are putting MicroPython on your board for the first time then you should first erase the entire flash using:

esptool.py --chip esp32s3 --port /dev/ttyACM0 erase_flash

From then on program the firmware starting at address 0:

esptool.py --chip esp32s3 --port /dev/ttyACM0 write_flash -z 0 board-20210902-v1.17.bin